© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

The essay develops two major arguments. First, if John Buridan's 'first argument' for the reintroduction of natural supposition is only that the "eternal truth" of a scientific proposition is preserved because subject terms in scientific propositions supposit for all the term's past, present, and future significata indifferently; then Albert of Saxony thinks it is simply ineffective. Only the 'second argument', i.e. the argument for the existence of an 'atemporal copula', adequately performs this task; but is rejected by Albert. Second, (...) later fourteenth-century criticisms of Buridan's natural supposition, given in certain Notabilia from the anonymous author in, Paris, BnF, lat. 14.716, ff. 40va-41rb, are nothing but an interpolated hodge-podge of criticisms given earlier in the century against various views of Buridan's by Albert of Saxony. It is this fact that makes Albert the real source of late fourteenth-century criticisms of Buridan's view of natural supposition. (shrink)

It is a mixed pleasure to see F. Matthias Alexander acknowledged in the fall 2007 issue of Education and Culture ("Dewey, women, and weirdoes: Or, the potential rewards for scholars who dialog across difference," 23[2], 27-62). As a professional descendant of Alexander who has been teaching the Alexander Technique (AT) for 30 years, I am glad to see Cunningham et al. including him in the list of positive influences in John Dewey's life. However, I believe Cunningham's contribution to this (...) article, "Shared explorations of body-mind: The reciprocal influences of Dewey and F. M. Alexander," falls short in its acknowledgement of Alexander and in one important aspect is incorrect. In this response, I hope to set the .. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 23 (2003) 147-148 [Access article in PDF] Buddhists and Christians: Praying for Peace in the World Archbishop Michael L. Fitzgerald Pontifical Council for Interreligious Dialogue Dear Buddhist Friends:As the new president of the Pontifical Council for Interreligious Dialogue, the office of His Holiness the Pope for relations with people of different religious traditions, I wish to greet you and send this congratulatory message on the occasion (...) of the feast of Vesakh. This gesture of friendship, initiated in 1995 by my predecessor Cardinal Francis Arinze, has almost become a tradition. I wish to continue this good tradition and express my hearty congratulations to each and every one of you.In this message, I would like to invite you, my dear Buddhist friends, to join in prayer for the cause of peace in the world. Observing the current international situation, we cannot but be aware of the acuteness of the question of peace in our world. Since the beginning of this new millennium, marked by the dramatic events of September 11, 2001, we witness every day fresh scenes of bloodshed, violence, confrontation, and crisis in almost all parts of the world. In the midst of this grave situation, we cannot lead our lives without committing ourselves to advancing the cause of peace in the world.We Christians and Buddhists are convinced that the origin of all conflict is ultimately located in human hearts characterized by selfish desire, specifically by desire for power, domination, and wealth, often at the expense of others. It is also our common conviction that peace must inhabit people's hearts before it can become a social reality. For us, therefore, the most fundamental and efficient way to advance peace is to do our best to see that the deep-rooted selfishness of human hearts is overcome, so that people may be transformed into true artisans of peace.Pope John Paul II has proclaimed the year from October 2002 to October 2003 the Year of the Rosary of the Virgin Mary. He has earnestly encouraged the frequent recitation of the Rosary in order to pray for peace in the world. His wish to revive the practice of the Rosary is closely connected with the present historical circumstances, which need more than ever-constant supplication for the great gift of peace.My Buddhist friends, is it not a wonderful coincidence that you also have a lengthy tradition of using the Mala for prayer? The Rosary for Catholics and the [End Page 147] Mala for Buddhists are simple yet profound and meaningful prayer, despite essential differences in their form and content, based on our distinct doctrines and practices. For Catholics, the Rosary represents a most effective means of fostering contemplation of Jesus Christ. For Buddhists, the Mala is used to overcome the 108 Sinful Desires in order to reach the state of Nirvana. By virtue of their meditative character, these two prayers have in common a calming effect on those who pray them; they lead them to experience and to work for peace, and they produce fruits of love. For Catholics, the repetition and meditation of the holy names of the Persons of the Blessed Trinity and the Virgin Mary in the recitation of the Rosary makes us more willing to assimilate their love and compassion for others, especially for the poor and afflicted. In your Buddhist tradition, praying the Mala helps one to become a peacemaker.Dear Buddhist friends, these are the thoughts I wish to share with you this year. I am convinced that by persevering in prayer we will contribute to advancing peace in the world both now and in the future. May this peace be with you and your families on the feast of Vesakh and at all times.Archbishop Michael L. Fitzgerald, President © by Michael L. Fitzgerald. Reprinted by permission.... (shrink)

"[The authors] artfully piece together important essays in educational policy and philosophy. . . . The book deals in detail with such issues as teacher professionalization, moral responsibility of public schools, accountability, and ethical codes of practice. Must reading for teachers, administrators, and professors in schools and departments of education." --Choice.

Organised into three sections covering the place of semantics in linguistics, the description of sentence and word meanings, and current theoretical approaches to semantics, this book is aimed at undergraduates as well as general readers.

This book offers a revisionary account of key epistemological concepts and doctrines of St Thomas Aquinas, particularly his concept of scientia, and proposes an interpretation of the purpose and composition of Aquinas's most mature and influential work, the Summa theologiae, which presents the scientia of sacred doctrine, i.e. Christian theology. Contrary to the standard interpretation of it as a work for neophytes in theology, Jenkins argues that it is in fact a pedagogical work intended as the culmination of philosophical and (...) theological studies of very gifted students. Jenkins considers our knowledge of the principles of a science. He argues that rational assent to the principles of sacred doctrine, the articles of faith, is due to the influence of grace on one's cognitive powers, because of which one is able immediately to apprehend these propositions as divinely revealed. His study will be of interest to readers in philosophy, theology and medieval studies. (shrink)

Our concern in this paper is with the question of how irrational an intentional agent can be, and, in particular, with an argument Stephen Stich has given for the claim that there are only very minimal a priori requirements on the rationality of intentional agents. The argument appears in chapter 2 of The Fragmentation of Reason.1 Stich is concerned there with the prospects for the ‘reform-minded epistemologist’. If there are a priori limits on how irrational we can be, there are (...) limits to how much reform we could expect to achieve. With this in mind, Stich sets out to determine what a priori limits there are on irrationality by examining `a cluster of influential arguments aimed at showing that there are conceptual constraints on how badly a person can reason’ (p. 30). Stich aims to remove the threat of a priori limits on the project of reforming our cognitive practices by showing, first, that these influential arguments are bad arguments, and, second, that at best there are only minimal constraints on how irrational we can be.2 We aim to show three things. The first is that Stich’s own arguments against strong a priori limits on how badly a person can reason are unsuccessful, because Stich fails to take into account that the concept of rationality is an epistemic, not just a logical concept, and because he fails to take into account the connection between having a concept and being able to recognize conceptually simple inferences involving the concept. The second is that the position Stich argues for, on the basis of Richard Grandy’s principle of humanity, turns out not to be distinct from the one he rejects. The third is that, in any case, the position that Stich rejects in order to preserve some scope for the project of improving our reasoning is not only no danger to that project but must be presupposed by it. (shrink)

This study examines the use of a video news release in a specific story. Press coverage and editorial criticism in the case showed that journalists do not articulate sufficiently how the news owners' sway, through institutional controls, can lead to a hegemony of expedient action in the newsroom. Critical self-reflection by news workers will better enable journalists to ethically deliberate news choices that balance their responsibilities to owners, peers, and the public.

The topic of synthetic life has long been a subject for science fiction writers, philosophers, and even scientists. With the announcement in 2010 by renowned biologist J. Craig Venter that he and a team of scientists from the J. Craig Venter Institute (JCVI) had created a bacterial cell with chemically synthesized genome, discussions of synthetic life were no longer just conjecture.Humans had assembled nonliving components to make a living cell (Gibson et al. 2010). I was one of the leaders of (...) that endeavor, and this article will be a first-person account of how we made our cell, along with my conjectures about what will come next in the new fields of synthetic biology and synthetic genomics.Scanning electron .. (shrink)

In Romances with Schools, John Goodlad steps out from behind the public persona of distinguished scholar and advocate for public schooling to offer a moving personal account of a life devoted to educating the young. He deftly interweaves fascinating personal details with reflections on many of the larger issues in education that he has explored throughout his career.

The dorsal anterior cingulate cortex is a key node in the human salience network. It has been ascribed motor, pain-processing and affective functions. However, the dynamics of information flow in this complex region and how it responds to inputs remain unclear and are difficult to study using non-invasive electrophysiology. The area is targeted by neurosurgery to treat neuropathic pain. During deep brain stimulation surgery, we recorded local field potentials from this region in humans during a decision-making task requiring motor output. (...) We investigated the spatial and temporal distribution of information flow within the dACC. We demonstrate the existence of a distributed network within the anterior cingulate cortex where discrete nodes demonstrate directed communication following inputs. We show that this network anticipates and responds to the valence of feedback to actions. We further show that these network dynamics adapt following learning. Our results provide evidence for the integration of learning and the response to feedback in a key cognitive region. (shrink)

A useful linkage can be made between recent literature on the philosophy and ethics of place and Australian work on education for place responsiveness. Place education, which holds a creative tension between deep experience and critical awareness, has a central role to play in any practical expression of an ethic of place. The way forward is suggested by Stefanovic's mediated iterative process for group work and the suspension of outcome orientation and judgement to allow the experience to speak for itself (...) prior to critical reflection for individual work. Malpas's philosophy of place and experience provides a framework for understanding the importance of narrative in structuring and being structured by place, and the significance of childhood place memories. Narrative emerges as a 'central organising principle' of place and identity, and can be viewed as both stories that connect us and stories that make us different. Place responsiveness work in Australia presents the opportunity for constructive intercultural dialogue and embedding new narratives of sustainability in place. (shrink)

The new mass media technologies now make information processing and distribution more accessible to people globally. Marshall Mcluhan’s “global village” has given birth to a “global palour”. However, perpetrators of crimes now bask on the philosophy of communication media practitioners that people have the right to know what is happening within and outside their environment. This stance is rapidly dismantling, in an amazing fashion, the hitherto accorded respect for media ethics. Neil Postman, a New York media analyst, describes the creator (...) of technology as the list judge of its consequences, especially with regards to the technology of the media. True, every communication medium is potent with the possibility of occasioning other consequences not directly intended by it. This paper, therefore, attempts to bring to the fore the way communication media are inadvertently promoting crimes and terrorist activities globally. It is the stand of this paper that a global overhaul of mass communication media is needed for balance reportage that would bring about global and meaningful developments of human and material resources under an atmosphere of peace and mutual tolerance. (shrink)

Edmund D. Pellegrino, John Collins Harvey, Kevin T. Fitzgerald, SJ; Must the Church be Mute Lest Its Truths be Distorted? A Response to Engelhardt, Christian bi.